The Placental Barrier: the Gate and the Fate in Drug Distribution.

摘要: Optimal development of the embryo and fetus depends on placental passage gases, nutrients, hormones, waste products. These molecules are transferred across placenta via passive diffusion, carrier-mediated cellular uptake efflux, transcytosis pathways. The same mechanisms additionally control rate extent transplacental transfer drugs taken by pregnant mother. Essentially all cross to a certain extent, some accumulate in itself at levels that can even exceed those maternal plasma. Hence, not efficiently may indirectly affect fetal interfering with function. In this article, we describe key properties barrier their modulation medications. We highlight implications for pharmacotherapy novel approaches drug delivery women fetuses.