Peripheral and central dopamine receptors in respiratory control

摘要: The role of peripheral and central dopaminergic mechanisms in respiratory control was studied anesthetized cats. In one series, we simultaneously measured carotid chemoreceptor ventilatory responses to hypoxia hypercapnia before after a saturation dose intravenous domperidone, dopamine (D2) receptor antagonist. Both were augmented by domperidone essentially proportion, suggesting that they reflected the increase activity. Haloperidol which crosses into brain from blood, given subsequent did not further affect but attenuated without significantly altering those hypercapnia. Thus, additional effect haloperidol is mediated through involving chemoreflex pathway alone. another cats paralyzed artificially ventilated study step increases end-tidal PCO2 domperidone. Domperidone CO2. results support hypothesis both play significant modulatory control.