Comparative genomic hybridization detects an increased number of chromosomal alterations in large cell/anaplastic medulloblastomas.
作者： Charles G. Eberhart , John E. Kratz , Amy Schuster , Pat Goldthwaite , Kenneth J. Cohen
DOI: 10.1111/J.1750-3639.2002.TB00420.X
关键词:
摘要: We correlate chromosomal changes in medulloblastomas with histologic subtype, reporting the analysis of 33 medulloblastoma specimens by comparative genomic hybridization, and a subset fluorescence situ hybridization. Of tumors, 5 were desmoplastic/nodular, 10 histologically classic, 18 large cell/anaplastic. Chromosomal gains losses more common anaplastic than non-anaplastic ones. identified 4 c-myc amplification N-myc amplification; all 9 cell/anaplastic subtype. Additional regions high level included 2q14-22, 3p23, 5p14-pter, 8q24, 9p22-23, 10p12-pter, 12q24, 12p11-12, 17p11-12, Xp11. The majority these occurred cases. also found loss chromosome 17p 7 cases but no nonanaplastic medulloblastomas. Finally, we detected significantly increased overall number alterations (6.8/case) compared to ones (3.3/case). These findings support an association between myc oncogene amplification, loss, histology.
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