Control of viral infections by epigenetic-targeted therapy

摘要: Epigenetics is defined as the science that studies modifications of gene expression are not owed to mutations or changes in genetic sequence. Recently, strong evidences pinpointing toward a solid interplay between such epigenetic alterations and outcome human cytomegalovirus (HCMV) infection. Guided by previous possibly promising experimental trials immunodeficiency virus (HIV) reprogramming, latter paving road two major approaches control viral latency. Reactivating HCMV from latent phase (“shock kill” paradigm) alternatively repressing lytic reactivation phases (“block lock” epigenetic-targeted therapy represent encouraging options overcome latency shedding otherwise replication infectivity, which could lead eventually infection its complications. Not limited HIV HCMV, this concept similarly studied context hepatitis B C virus, herpes simplex Epstein-Barr virus. Therefore, manipulations stand pioneering research area modern biology constitute curative methodology potentially consenting development broad-spectrum antivirals infections vivo.