Tumor-induced immune dysfunctions caused by myeloid suppressor cells.

摘要: In the late 1970s, several findings suggested that accessory cells distinct from lymphocytes might suppress immune reactivity in tumor-bearing hosts. Studies animal models and patients later confirmed driven to act as dominant suppressors by growing cancers could subvert system. These have also been termed natural suppressors, a functional definition connoting their ability hamper various T- B-lymphocyte responses without prior activation independently antigen MHC restriction. properties were attributed cell populations. The phenotypic discrepancies, together with lack of specificity, generated serious restraints research on tumor-induced suppression. Recent evidence indicates suppressor are closely related immature myeloid precursors can be found situations exert adverse effects immunotherapy cancer. present review is an attempt address nature relationship dendritic macrophages, aim clarifying complex network tumor-induced, negative regulators