In vivo quantification of intraarticular cytokines in knees during natural and surgically induced cartilage repair.

摘要: Background aims Cartilage defects are considered to be an initial event in the progress of osteoarthritis. Reliable data about vivo regulation cytokines natural and surgically induced cartilage repair still missing. Methods Knee lavage fluids 47 patients were collected prospectively between August 2006 September 2007. Five without lesions served as a control group. In 42 treated by microfracturing (19) or autologous chondrocyte implantation (ACI) (23). Total protein content concentrations aggrecan, basic fibroblast growth factor (bFGF), Insulin-like interleukin (IL)-1 β determined. Clinical status was evaluated using Lysholm score. Results High-level expression all knees found for low-level constitutive bFGF IGF-I, while IL-1 group remained below detection levels. The concentration IGF-I with significantly higher ( P 2) , compared 2 increased correlated systemic C-reactive (CRP). score showed medium significant negative correlation Conclusions Aggrecan is constitutively expressed knee joints. seem play pivotal role surgical repair. Operative intervention additionally associated -related inflammation-like reactions.