Secular Changes in U.S. Prediabetes Prevalence Defined by Hemoglobin A1c and Fasting Plasma Glucose National Health and Nutrition Examination Surveys, 1999–2010

摘要: OBJECTIVE Using a nationally representative sample of the civilian noninstitutionalized U.S. population, we estimated prediabetes prevalence and its changes during 1999–2010. RESEARCH DESIGN AND METHODS Data were from 19,182 nonpregnant individuals aged ≥12 years who participated in 1999–2010 National Health Nutrition Examination Surveys. We defined as hemoglobin A 1c 5.7 to RESULTS Among those years, age-adjusted increased 27.4% (95% CI 25.1–29.7) 1999–2002 34.1% (32.5–35.8) 2007–2010. adults ≥18 29.2% (26.8–31.8) 36.2% (34.5–38.0). As single measures among A1C5.7 9.5% (8.4–10.8) 17.8% (16.6–19.0), relative increase 87%, whereas IFG remained stable. These similar total across subgroups, after controlling for covariates. CONCLUSIONS During 1999–2010, because increases A1C5.7. Continuous monitoring is needed identify, quantify, characterize population high-risk targeted ongoing diabetes primary prevention efforts.