Short-term studies on the use of glycerol as an osmotic agent in continuous ambulatory peritoneal dialysis (CAPD)

摘要: The use of glycerol as an osmotic agent in two different concentrations (92 mmol/l and 272 mmol/l) peritoneal dialysis fluid was investigated over 3 days six patients on continuous ambulatory compared with glucose (76 215 the same patients. calorific value absorbed lower, by 19% isotonic 22% hypertonic solutions, when used place glucose. However, provided significantly lower total ultrafiltration than at each concentration, despite a higher initial pressure glycerol-based solutions. Thus, concentration required to provide equal may offset any advantage. Equilibration creatinine urea slower clearance glycerol. Solutions containing were initially less acid (pH 6.5) those 5.1). Blood levels, which physiological range agent, reached peak 80-fold greater 4.3 +/- 0.8 during eightfold 0.42 0.09 92 mmol/l. There no evidence haemolysis or other toxic effect these levels. rise blood insulin noted glucose-based solutions not found Circulating levels lactate, pyruvate, alanine, non-esterified fatty acids ketone bodies similar agents. Although short-term studies have shown conclusive advantage glucose, long-term effects glycerol, particularly circulating lipid will determine its future role dialysis.