Recombinant expression, molecular characterization and crystal structure of antitumor enzyme, L-lysine α-oxidase from Trichoderma viride*
作者： M. Amano , H. Mizuguchi , T. Sano , H. Kondo , K. Shinyashiki
DOI: 10.1093/JB/MVV012
关键词:
摘要: L-Lysine α-oxidase (LysOX) from Trichoderma viride is a homodimeric 112 kDa flavoenzyme that catalyzes the oxidative deamination of L-lysine to form α-keto-e-aminocaproate. LysOX severely inhibited growth cancer cells but showed relatively low cytotoxicity for normal cells. We have determined
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