Age-related differences in kidney injury biomarkers induced by cisplatin

摘要: Acute kidney injury (AKI) occurs in a half of cisplatin (CDDP)-treated patients. Traditional biomarkers including blood urea nitrogen (BUN) and serum creatinine (SCr) are still used for detection CDDP-induced AKI, but these not specific or sensitive. The aim this study was to identify the sensitive against renal between young (3-week-old) old (20-week-old) rats. All animals were intraperitoneally injected once with CDDP (6 mg/kg). After 3 days, all sacrificed serum, urine, tissues collected. Urinary as well histological changes measured. proximal tubular damage apparent from histopathological examination, being more severe 3-week-old rats accompanied by increased number TUNEL-positive apoptotic cells. This associated elevated urinary molecule-1 (KIM-1), glutathione-S-transferase alpha (GST-α), vascular endothelial growth factor (VEGF), tissue inhibitor metalloproteinases-1 (TIMP-1). In contrast, levels neutrophil gelatinase-associated lipocalin (NGAL) osteopontin significantly 20-week-old after treatment. These results indicate that use age-specific is necessary diagnosis AKI. Especially, KIM-1, GST-α, TIMP-1, VEGF may help early patients