Total serum IgE levels in systemic lupus erythematosus and associations with childhood onset allergies.

摘要: Elevated serum IgE has been described in systemic lupus erythematosus (SLE), but associations with disease risk and characteristics remain unresolved. We assessed total levels atopy (IgE > 100 IU/ml) recently diagnosed SLE patients (n = 228) compared population controls 293) relation to activity, autoantibodies, clinical features, immunoglobulins, C-reactive protein, allergy history. Multivariate models estimated determinants of controls, atopy. Total were higher than (median 42 vs. 29 IU/ml); 32% 25% atopic (p 0.06). significantly non-Whites reporting childhood onset (<18 years) asthma hives, asthma, hay fever, eczema, adult hives. After accounting for racial differences, was not associated SLE, nephritis, or other laboratory parameters. In sum, our findings provide limited evidence a direct association between overall after adjusting demographic Future studies may want explore potentially shared factors development allergy, atopy, SLE.