ERK1/2 has an essential role in B cell receptor- and CD40-induced signaling in an in vitro model of germinal center B cell selection
作者： Jemal Adem , Aleksi Hämäläinen , Antti Ropponen , Jonna Eeva , Mine Eray
DOI: 10.1016/J.MOLIMM.2015.05.017
关键词:
摘要: Germinal center (GC) B cells undergo apoptosis after cell receptor (BCR) ligation, unless they receive CD40-mediated survival signal from helper T cells. In the present study, we used a human follicular lymphoma line HF1A3, as an in vitro model to study selection process germinal centers. We show here that BCR ligation led immediate ERK1/2 activation and phosphorylations of its downstream targets, Bim EL/L Bcl-2 (at Ser70) which resulted short-term survival. On other hand, during late phase signaling, phosphorylation was inhibited apoptosis. addition, CD40 signaling sustained up-regulation Bcl-xL BCR-primed HF1A3 GC conclusion, MEK-ERK pathway family proteins are crucial players BCR-mediated survival/apoptosis
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