RIP1 has a role in CD40-mediated apoptosis in human follicular lymphoma cells.
作者： Jemal Adem , Mine Eray , Jonna Eeva , Ulla Nuutinen , Jukka Pelkonen
DOI: 10.1016/J.IMBIO.2017.06.001
关键词:
摘要: CD40 is a cell surface receptor which belongs to tumor necrosis factor (TNFR) family members. It transmits signals that regulate diverse cellular responses such as proliferation, differentiation, adhesion molecule expression and apoptosis. Unlike other TNFR members (TRAIL-R, Fas-R TNFR1), the cytoplasmic tail lacks death domain. However, capable of inducing apoptosis in different types cancer cells including lymphoma. The apoptotic effect linked involvement Fas, TRAIL or interacting protein 1 (RIP1) kinase. We have previously shown activation has anti-apoptotic follicular lymphoma (FL) lines. In this study, we investigated mechanism by mediates line, HF4.9. show here CD40-induced was dependent on caspase-8 because specific inhibitor, Z-IETD-FMK completely prevented Therefore, TRAIL, Fas RIP1 examined. exogenous TRAIL-induced fully anti-TRAIL neutralizing antibody. antibody had no indicating did not induce endogenous HF4.9 cells. Moreover, were sensitive Fas-mediated Interestingly, necrostatin-1 decreased apoptosis, showed role activation. conclusion, survival effects CD40-mediated signaling might be related differentiation stages FL
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