Necroptosis in head and neck squamous cell carcinoma: characterization of clinicopathological relevance and in vitro cell model
作者： Jingyuan Li , Sihui Huang , Lijuan Zeng , Kan Li , Le Yang
DOI: 10.1038/S41419-020-2538-5
关键词:
摘要: Necroptosis is a recently discovered form of programmed cell death (PCD) having necrotic-like morphology. However, its presence and potential impact with respect to head neck squamous carcinoma (HNSCC) are still unknown. The aim this study was reveal the necroptosis status clinicopathological relevance in HNSCC establish an vitro model. We first analyzed level p-MLKL, MLKL, tumor necrosis patient tissues as well their correlation features. Results showed that approximately half can be attributed necroptosis, extent independent prognostic marker for patient's overall survival progression-free survival. Then we established thoroughly verified model two lines using combined treatment TNF-α, Smac mimetic zVAD-fmk (TSZ). At last, adopted demonstrated promote migration invasion cells by releasing damage-associated molecular patterns. In conclusion, our unveiled necroptotic time provided novel lines. addition, results indicated may cancer promoter HNSCC. This serve foundation future researches
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