Extracellular Matrix Abnormalities in Schizophrenia

摘要: Emerging evidence points to the involvement of brain extracellular matrix (ECM) in pathophysiology schizophrenia (SZ). Abnormalities affecting several ECM components, including Reelin and chondroitin sulfate proteoglycans (CSPGs), have been described subjects with this disease. Solid supports Reelin, an glycoprotein involved corticogenesis, synaptic functions glutamate NMDA receptor regulation, expressed prevalently distinct populations GABAergic neurons, which secrete it into ECM. Marked changes expression SZ typically reported association GABA-related abnormalities bipolar disorder. Recent findings from our group point substantial CSPGs, a main component, amygdala entorhinal cortex schizophrenia, but not Striking increases glial cells expressing CSPGs were accompanied by reductions perineuronal nets, CSPG- Reelin-enriched aggregates enveloping neuronal populations. developmental adult functions, migration, axon guidance, neurotransmission regulation are highly relevant SZ. Together reports anomalies other these as key component pathology We propose that may contribute aspects disease, disrupted connectivity altered GABAergic, glutamatergic dopaminergic neurotransmission.