Chlorotriazines do not activate the aryl hydrocarbon receptor, the oestrogen receptor or the thyroid receptor in in vitro assays.
作者： Irene de la Casa-Resino , José M. Navas , María L. Fernández-Cruz
DOI: 10.1177/026119291404200105
关键词:
摘要: Atrazine, prometryn, propazine and simazine are chlorotriazines that commonly employed as herbicides. However, their use is a major cause of concern, due to reported endocrine disrupting effects in different taxa. Data from studies on the molecular cellular processes underlying hormonal action these substances contradictory. The ability atrazine metabolites, desethyl-s-chlorotriazine desisopropyl-s-chlorotriazine, trigger responses mediated by oestrogen receptor (ER), aryl hydrocarbon (AhR) thyroid (TR), was studied using vitro approaches. Transcriptional activation assays were applied observe ER TR. induction ethoxyresorufin-O-deethylase (EROD) activity RTG-2 cell line served an indicator AhR activation. No found any assays, with six tested. Our observations indicate tested unlikely via receptors.
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