Role of Immunity in the Clearance of Bacteremia Due to Haemophilus influenzae

摘要: The role of antibodies to capsular and somatic antigens in the clearance Haemophilus influenzae was investigated by active passive immunization. index (k) proportion strain b organisms cleared 30 min after intravenous administration (deltaY30) were greater eight-week-old actively immunized rats (k = 0.693, deltaY30 4.07) than nonimmune animals 0.075, 0.95)(P less 0.025 for all); however, correlated imprecisely with titers bactericidal or anticapsular antibody. In three-week-old rats, intranasal immunization U significantly increased (P 0.005) rate strains U. Passive 0.001) bacteria 0.05) all test strains. associated splenic uptake 32P-labeled H. (r 0.83, P 0.025). Analysis disappearance viable bacterial 32P suggested that bacteriolysis did not occur during bacteremia. Either antibody antigen antigen, administered evoked accelerates promotion reticuloendothelial phagocytosis.