Suppression of arthritis and protection from bone destruction by treatment with TNP-470/AGM-1470 in a transgenic mouse model of rheumatoid arthritis

摘要: Objective We assessed the clinical and histologic features of angiogenesis inhibition in a transgenic mouse model arthritis that closely resembles rheumatoid (RA) humans. Methods KRN/NOD mice, which spontaneously develop arthritis, were treated with TNP-470, an inhibitor. Disease was monitored by use indices examinations; circulating blood levels vascular endothelial growth factor determined enzyme-linked immunosorbent assay. Results In preventive protocol, TNP-470 administration at dosage 60 mg/kg body weight, onset delayed its intensity rather mild; 100% placebo-treated mice developed led to severe articular destruction. At 90 appearance signs for longer period time disease almost abolished. The therapeutic regimen alleviated only when given during very early stage disease. Reductions cartilage bone destruction treatment observed histologically, feature still evident 30 80 days after injections withdrawn. Conclusion Our demonstration vivo inhibitor suppresses protects from provides new insight into pathogenesis opens possibilities RA humans.