Breast Cancer: Expression of HER-2 and Epidermal Growth Factor Receptor as Clinical Markers for Response to Targeted Therapy
作者： Stanley E. Shackney , David R. Emlet , Russell Schwartz , Kathryn A. Brown , Agnese A. Pollice
DOI: 10.1007/978-1-4020-8369-3_32
关键词:
摘要: In this chapter we consider the relationships that involve both HER-2 and epidermal growth factor receptor (EGFR), with a particular focus on potential use of these two transmembrane receptors as biomarkers for predicting response to targeted therapeutic agents directed at either or them. Effective clinical depends an understanding their complex biological interactions, awareness shortcomings current methods measuring cellular constituents in setting. Here will review selected aspects topics, attempt develop working hypotheses organizing principles might be useful translating basic knowledge into practice. CELL AND MOLECULAR BIOLOGY OF HER-2/EPIDERMAL GROWTH FACTOR RECEPTOR INTERACTIONS
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