Elevated Levels of Epidermal Growth Factor Receptor/c-erbB2 Heterodimers Mediate an Autocrine Growth Regulatory Pathway in Tamoxifen-Resistant MCF-7 Cells
作者： Janice M. Knowlden , Iain R. Hutcheson , Helen E. Jones , Tracieann Madden , Julia M. W. Gee
关键词:
摘要: … heterodimers were detected in TAM-R cells in association with increased levels of phosphorylated extracellular-… and c-erbB2 protein or a specific increase in receptor phosphorylation. …
oup.com
pubpeer.com
core.ac.uk
endocrine.org参考文章(60)
EGF receptor in tumor growth and progression Springer. ,(1997) , 10.1007/978-3-662-03391-3
Anne E. Lykkesfeldt, Per Briand, Mogens W. Madsen, Altered expression of estrogen-regulated genes in a tamoxifen-resistant and ICI 164,384 and ICI 182,780 sensitive human breast cancer cell line, MCF-7/TAMR-1. Cancer Research. ,vol. 54, pp. 1587- 1595 ,(1994)
Thomas Grunt, Cheryl Cho, Caroline Waibel, Ruth Lupu, Cynthia Perez, Careen K. Tang, Involvement of Heregulin-β2 in the Acquisition of the Hormone-independent Phenotype of Breast Cancer Cells Cancer Research. ,vol. 56, pp. 3350- 3358 ,(1996)
Thomas L. Frandsen, Thomas L. Frandsen, Mian Bei, Marc E. Lippman, Erik W. Thompson, Robert Clarke, Nils Brünner, Claus Holst-Hansen, Alan E. Wakeling, MCF7/LCC2: A 4-hydroxytamoxifen resistant human breast cancer variant that retains sensitivity to the steroidal antiestrogen ICI 182,780 Cancer Research. ,vol. 53, pp. 3229- 3232 ,(1993)
D. El-Ashry, F. G. Kern, Yiliang Liu, A. L. Cheville, D. L. Miller, S. W. Mcleskey, Emergence of MCF-7 cells overexpressing a transfected epidermal growth factor receptor (EGFR) under estrogen-depleted conditions: Evidence for a role of EGFR in breast cancer growth and progression Cell Growth & Differentiation. ,vol. 5, pp. 1263- 1274 ,(1994)
R I Nicholson, J M W Gee, Oestrogen and growth factor cross-talk and endocrine insensitivity and acquired resistance in breast cancer British Journal of Cancer. ,vol. 82, pp. 501- 513 ,(2000) , 10.1054/BJOC.1999.0954
Carlos L. Arteaga, James T. Forbes, Paul I. Pisacane, Jean F. Simpson, Hirokazu Kurokawa, Mark X. Sliwkowski, Anne E. G. Lenferink, Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells. Cancer Research. ,vol. 60, pp. 5887- 5894 ,(2000)
P. C. Willsher, S. E. Pinder, S. Y. Chan, Robert Ian Nicholson, Julia Margaret Wendy Gee, J. F. R. Robertson, R. W. Blamey, I. O. Ellis, C-erbB2 expression predicts response to preoperative chemotherapy for locally advanced breast cancer. Anticancer Research. ,vol. 18, pp. 3695- 3698 ,(1998)
B Long, BM McKibben, M Lynch, HW van den Berg, Changes in epidermal growth factor receptor expression and response to ligand associated with acquired tamoxifen resistance or oestrogen independence in the ZR-75-1 human breast cancer cell line. British Journal of Cancer. ,vol. 65, pp. 865- 869 ,(1992) , 10.1038/BJC.1992.182
Venkateshwar G. Keshamouni, Raymond R. Mattingly, Kaladhar B. Reddy, Mechanism of 17-β-Estradiol-induced Erk1/2 Activation in Breast Cancer Cells A ROLE FOR HER2 AND PKC-δ Journal of Biological Chemistry. ,vol. 277, pp. 22558- 22565 ,(2002) , 10.1074/JBC.M202351200