New bioactive triterpenoids and antimalarial activity of Diospyros rubra Lec.
作者： Virapong Prachayasittikul , Somsak Ruchirawat , Rungrot Cherdtrakulkiat , Puttirat Saraban , Supaluk Prachayasittikul
DOI: 10.17877/DE290R-8933
关键词:
摘要: The first investigation of the chemical constituents and bioactivities Diospyros rubra Lec. is reported. D. extracts were screened for antimicrobial, antimalarial cytotoxic activities. They only shown to be active antimalarials. with good activity isolated extensively purified give lupeol (1), lupenone (2), betulin (3), acetate (4), 28-O-acetylbetulin (5), β-sitosteryl-3-O-β-D-glucopyranoside (6) a mixture β-sitosterol stigmasterol. Some isolates tested antimicrobial actions. Betulin (3) displayed against Streptococcus pyogenes minimum inhibitory concentration (MIC) 85 μg/mL. Interestingly, bioactive fractions all selectively exerted some Corynebacterium diphtheriae NCTC 10356 MIC range 64-256 study provides data support medicinal importance rubra.
tu-dortmund.de 
researchgate.net 
sci-hub.st 参考文章(23)
C.R. Mitra, G. Misra, Mimusops hexandra—I. Phytochemistry. ,vol. 4, pp. 345- 348 ,(1965) , 10.1016/S0031-9422(00)86183-X
Winston F. Tinto, Lynn C. Blair, Azzam Alli, William F. Reynolds, Stewart McLean, Lupane triterpenoids of Salacia cordata Journal of Natural Products. ,vol. 55, pp. 395- 398 ,(1992) , 10.1021/NP50081A020
W Trager, J. Jensen, Human malaria parasites in continuous culture Science. ,vol. 193, pp. 673- 675 ,(1976) , 10.1126/SCIENCE.781840
KUNITOSHI YOSHIHIRA, MICHIKO TEZUKA, PANIDA KANCHANAPEE, SHINSAKU NATORI, Naphthoquinone Derivatives from the Ebenaceae. I. Diospyrol and the Related Naphthoquinones from Diospyros mollis GRIFF. Chemical & Pharmaceutical Bulletin. ,vol. 19, pp. 2271- 2277 ,(1971) , 10.1248/CPB.19.2271
Miroslav Kvasnica, Jan Sarek, Eva Klinotova, Petr Dzubak, Marian Hajduch, Synthesis of phthalates of betulinic acid and betulin with cytotoxic activity. Bioorganic & Medicinal Chemistry. ,vol. 13, pp. 3447- 3454 ,(2005) , 10.1016/J.BMC.2005.03.006
N.I. Pavlova, O.V. Savinova, S.N. Nikolaeva, E.I. Boreko, O.B. Flekhter, Antiviral activity of betulin, betulinic and betulonic acids against some enveloped and non-enveloped viruses. Fitoterapia. ,vol. 74, pp. 489- 492 ,(2003) , 10.1016/S0367-326X(03)00123-0
Tasanee Tengchaisri, Runglawan Chawengkirttikul, Nattawan Rachaphaew, Vichai Reutrakul, Ranee Sangsuwan, Stitaya Sirisinha, Antitumor activity of triptolide against cholangiocarcinoma growth in vitro and in hamsters. Cancer Letters. ,vol. 133, pp. 169- 175 ,(1998) , 10.1016/S0304-3835(98)00222-5
Betânia Barros Cota, Alaı́de Braga de Oliveira, José Dias de Souza-Filho, Fernão Castro Braga, Antimicrobial activity and constituents of Coccoloba acrostichoides Fitoterapia. ,vol. 74, pp. 729- 731 ,(2003) , 10.1016/J.FITOTE.2003.08.003
Chris Lambros, Jerome P. Vanderberg, Synchronization of Plasmodium falciparum erythrocytic stages in culture. Journal of Parasitology. ,vol. 65, pp. 418- 420 ,(1979) , 10.2307/3280287
María del Carmen Recio, Rosa Giner, S. Máñez, J. Gueho, H. Julien, K. Hostettmann, J. Ríos, Investigations on the steroidal anti-inflammatory activity of triterpenoids from Diospyros leucomelas. Planta Medica. ,vol. 61, pp. 9- 12 ,(1995) , 10.1055/S-2006-957988