Prospects for novel inhibitors of peptidoglycan transglycosylases.

摘要: The lack of novel antimicrobial drugs under development coupled with the increasing occurrence resistance to existing antibiotics by community and hospital acquired infections is grave concern. targeting biosynthesis peptidoglycan component bacterial cell wall has proven be clinically valuable but relatively little therapeutic been directed towards transglycosylase step this process. Advances isolation new antimicrobials that target activity will rely on enzymological tools required identify characterise inhibitors these enzymes. Therefore, in article, we review assay methods developed for transglycosylases recent chemical discovered relation both lipidic substrates natural product step.