Relationship between irradiation-induced neuro-inflammatory environments and impaired cognitive function in the developing brain of mice
作者： Xiaorong Dong , Ming Luo , Guodong Huang , Jian Zhang , Fan Tong
DOI: 10.3109/09553002.2014.988895
关键词:
摘要: AbstractPurpose: Radiation-induced brain injury (RIBI) is the most common side-effect after cranial radiation therapy (CRT). In present study, RIBI mice model was established and changes in expression of tumor necrosis factor alpha (TNF-α) interleukin-1beta (IL-1β) mRNA, related signal pathways hippocampus this were investigated.Materials methods: 10 Gy CRT or sham-irradiation given to three-week old mice. The water maze test used pro-inflammatory cytokines detected by real-time polymerase chain reaction (PCR) vivo. microglial activation neurogensis analyzed immunofluorescence immunohistochemistry. cytoplasm nuclei translocation Nuclear kappa B (NF-κB), protein expressions IkappaB-alpha (IκB-α), NF-κB essential modulator (NEMO), p53-induced with a death domain (PIDD), TNF-α IL-1β examined Weste...
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