Identification of Key Gene Signatures Associated With Bone Metastasis in Castration-Resistant Prostate Cancer Using Co-Expression Analysis.

摘要: About 80-90% of castration-resistant prostate cancer (CRPC) patients would develop bone metastasis. However, the molecular mechanisms metastasis are still not clear. This study aimed to detect differences between tumor and normal samples in after metastatic colonization. Four transcriptional datasets (GSE32269, GSE101607, GSE29650, GSE74685) were obtained from GEO database. 1983 differentially expressed genes (DEGs) first identified marrow GSE32269. Most top 10 up-regulated DEGs related with cancer, down-regulated mainly development. Seven co-expression modules then detected based on 1469 shared by four datasets. Three them found highly preserved among Enrichment analysis showed that three respectively enriched Cell adhesion molecules (CAMs), Leukocyte transendothelial migration cell cycle, which might play significantly important roles development marrow. Ten, 17, 99 hub for each module identified. And (C3AR1, IL10RA, LY86, MS4A6A) be tightly progression CRPC. ROC curve was plotted AUC calculated distinguish as well non-bone CRPCs. The present key involved CRPCs, may provide new insights biomarkers understanding