RALBP1/RLIP76 mediates multidrug resistance.
作者： Kenneth Drake , Jyotsana Singhal , Sushma Yadav , Aalok Nadkar , Chirag Pungaliya
DOI: 10.3892/IJO.30.1.139
关键词:
摘要: RLIP76/RALBP1 is a multi-specific drug-transporter which can mediate drug-resistance in lung and other cancers, but its ability to multidrug-resistance has not been previously demonstrated hematological malignancy. Present studies K562 human myelogenous leukemia show that RALBP1 overexpression confers broad resistance multiple chemotherapy drugs including cisplatin, melphalan, doxorubicin, daunorubicin, vincristine, vinblastine, vinorelbine, mitomycin-C. Conversely, inhibition of by polyclonal antibodies causes increased drug-accumulation cytotoxicity. These demonstrate the potential utility targeting treatment leukemia.
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