Potential of regenerative medicine techniques in canine hepatology

摘要: Liver cell turnover is very slow, especially compared to intestines and stomach epithelium hair cells. Since the liver main detoxifying organ in body, it does not come as a surprise that has an unmatched regenerative capacity. After 70% partial hepatectomy, size returns normal about two weeks due replication of differentiated hepatocytes cholangiocytes. Despite this, diseases are regularly encountered veterinary clinic. Dogs primarily present with parenchymal pathologies such hepatitis. The estimated frequency canine hepatitis depends on investigated population accounts for 1%–2% our university clinic referral population, up 12% general population. In chronic severe acute disease, replicative capacity and/or cholangiocytes falls short restored. this situation, proliferation hepatic stem cells or progenitor (HPCs), histology ...