Glycine selectively reduces intestinal injury during endotoxemia

摘要: Abstract Background Glycine is well known to protect the intestine against ischemia–reperfusion injury and during mechanical manipulation. Here, we studied whether glycine protects small endotoxemia, even without being site of infection. Materials methods Lipopolysaccharide (LPS) was infused at a rate 1 mg/kg × h over period 7 h (subacute endotoxemia) in male Wistar rats. (single dose: 50 mg/kg 15 min) applied intravenously 180 270 min after beginning LPS infusion. Systemic parameters were periodically determined. The analyzed for macroscopic (hemorrhages) histopathologic changes (hematoxylin eosin staining), markers inflammation (myeloperoxidase activity). Results neither decreased mortality nor beneficially affected vital (e.g., mean arterial blood pressure breathing rate), electrolytes, gases including pH base excess, plasma tissue such as lactate concentration, hemolysis, aminotransferases activities experimental endotoxemia. It, however, specifically diminished LPS-induced intestinal injury, indicated by less accumulation blood, hemorrhages, reduced hemoglobin content. Conclusions present results demonstrate that selectively subacute manifestation severe systemic impairment. Because non-toxic low doses, an administration moderate dose (50–100 mg/kg) may be suitable from damage sepsis. Its true clinical potential, needs verified further studies trials.