Glycine, a simple physiological compound protecting by yet puzzling mechanism(s) against ischaemia–reperfusion injury: current knowledge

摘要: Ischaemia is amongst the leading causes of death. Despite this importance, there are only a few therapeutic approaches to protect from ischaemia–reperfusion injury (IRI). In experimental studies, amino acid glycine effectively protected IRI. prevention IRI by in cells and isolated perfused or cold-stored organs (tissues), direct cytoprotection plays crucial role, most likely formation pathological plasma membrane pores. Under vivo conditions, mechanism protection less clear, partly due physiological presence acid. Here, inhibition inflammatory response injured tissue considered contribute decisively glycine-induced reduction However, attenuation recently achieved animals low-dose treatment regimens suggests additional/other (unknown) protective mechanisms. convincing evidence large width glycine, clinical trials on with ambivalent results. Thus, both mechanism(s) behind against its true potential remain be addressed future studies/clinical trials.