Effects of glycine, pyruvate, resveratrol, and nitrite on tissue injury and cytokine response in endotoxemic rats

摘要: Abstract Background Glycine, pyruvate, resveratrol, and nitrite are well-known protective compounds among others in ischemic tissue injury. Here, we compared their effects acute lipopolysaccharide (LPS)-induced shock rats to assess whether inhibition of the proinflammatory cytokine response is a prerequisite for actions. Materials methods Rats (six or eight per group) were anesthetized, received LPS as an intravenous bolus (2.5 mg/kg), observed 5 h. sodium continuously infused starting 30 min before administration. Parameters included histopathologic changes, organ-specific levels, plasma nitrate concentrations, time courses biomonitoring parameters, marker enzyme activities, concentrations. Results enhanced arterial blood pressure after LPS-induced shock. Also, parameters reflecting ischemia significantly improved markers organ injury ameliorated by all substances. Of concentrations increased LPS, some differently decreased even further None them reduced elevated concentration. Glycine diminished increases levels specifically, pyruvate organs, affected only few whereas many cytokines raised resveratrol. All substances except resveratrol granulocyte infiltrates liver. Conclusions The present results demonstrate that glycine, protect against (cell death) suggest not mandatory