Gastric cancer: clinical aspects, epidemiology and molecular background.

摘要: The validity and usefulness of the 7th edition UICC tumor node metastasis classification in context clinical management gastric cancer are discussed. most relevant new agent therapy is trastuzumab for HER2-positive carcinomas. This marks success continuous effort translational research. Trastuzumab, initially applied palliative settings, currently being evaluated also neoadjuvant treatment regimens. Several meta-analyses support carcinogenic effect high salt intake smoking Helicobacter pylori infection. Further data have become available on efficacy protective agents, acetyl salicylic acid/nonsteroidal anti-inflammatory drugs, antioxidants. In search a successful prevention strategy, focus identification individuals at risk who demand screening (testing) surveillance. Serological assessment mucosal abnormalities with increased development extensively studied, presented from Asia as well Europe. New high-throughput techniques combined bioinformatic vector analysis open gate to potential diagnostic therapeutic targets. Furthermore, these approaches allow us elucidate interplay bacterial virulence factors host's immune response H. pylori-associated alterations gene expression.