Teratogenic compounds ofVeratrum californicum (Durand). X. Cyclopia in rabbits produced by cyclopamine
作者： Richard F. Keeler
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摘要: Cyclopamine, the compound responsible for cyclopia in sheep upon maternal ingestion of Veratrum californicum, produced and related cephalic malformations rabbits when orally administered with CaCO3 as a stomach-acid buffer to prevent acid-induced conversion veratramine, devoid similar teratogenic activity. The insult period was between days 6 9 gestation. Both vitro vivo experiments suggested nonbuffered cyclopamine veratramine under conditions.
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Richard F. Keeler, Wayne Binns, Teratogenic compounds of Veratrum californicum (Durand). I. Preparation and characterization of fractions and alkaloids for biologic testing. Biochemistry and Cell Biology. ,vol. 44, pp. 819- 828 ,(1966) , 10.1139/O66-100
Tadashi Masamune, Yoichi Mori, Mitsuo Takasugi, Akio Murai, Shigehiro Ohuchi, Norio Sato, Nobukatsu Katsui, 11-Deoxojervine, a new alkaloid from Veratrum species. Bulletin of the Chemical Society of Japan. ,vol. 38, pp. 1374- 1378 ,(1965) , 10.1246/BCSJ.38.1374
Richard F. Keeler, Wayne Binns, Teratogenic compounds of Veratrum californicum (Durand). V. Comparison of cyclopian effects of steroidal alkaloids from the plant and structurally related compounds from other sources Teratology. ,vol. 1, pp. 5- 10 ,(1968) , 10.1002/TERA.1420010103
Richard F. Keeler, Teratogenic compounds inVeratrum californicum (Durand). IX. Structure-activity relation Teratology. ,vol. 3, pp. 169- 173 ,(1970) , 10.1002/TERA.1420030209
William E. Johnson, Arnold R. Martin, Nonteratogenicity of Veratrum californicum in rabbits Journal of Pharmaceutical Sciences. ,vol. 58, pp. 1165- 1166 ,(1969) , 10.1002/JPS.2600580936
L F James, G Everett, J L Shupe, W Binns, A CONGENITAL CYCLOPIAN-TYPE MALFORMATION IN LAMBS INDUCED BY MATERNAL INGESTION OF A RANGE PLANT, VERATRUM CALIFORNICUM. American Journal of Veterinary Research. ,vol. 24, pp. 1164- 1175 ,(1963)