Effects of growth factors and cytokines on osteoblast differentiation

摘要: The therapeutic management of new bone formation remains one the key issues in periodontology and dental implantology. A full understanding nature bone-forming cells (osteoblasts) their lineage, factors that may regulate osteoblast behavior locally, how these different regulatory mechanisms could interact, has been subject extensive study for many years, particularly with aspiration such an will lead to development novel biologically based therapies regeneration, not only applications but also other disciplines, as orthopedic surgery, maxillofacial craniofacial surgery. aim this review was follows. • describe phenotype, its lineage genetic regulation differentiation function. discuss role a range cytokines growth regulating some cytokine pathways be regulated interact each co-ordinated control review, briefly, studies have investigated pharmacological application locally vivo. Cytokines are soluble, secreted glycoproteins which act local signaling molecules co-ordinate cellular They function ligands bind cell-surface receptors, triggering series intracellular events, ultimately resulting modulation gene expression target cells. Growth generally considered subset anabolic physiological pathophysiological roles tissue healing. Although terminology is widely used, distinction between probably artificial one, given complex all on cell However keeping convention, here we used term distinct subgroup cytokines, separately associated inflammation regulation.