A ruthenium-based 5-fluorouracil complex with enhanced cytotoxicity and apoptosis induction action in HCT116 cells.
作者： Valdenizia Rodrigues Silva , Rodrigo S. Corrêa , Luciano de Souza Santos , Milena Botelho Pereira Soares , Alzir Azevedo Batista
DOI: 10.1038/S41598-017-18639-6
关键词:
摘要: … -IR experiment is that in metal complex only one carbonyl group of 5-FU is coordinated to … methylimidazole complex caused cell cycle arrest at G 0 /G 1 phase and induced apoptosis via …
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Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie Bray, Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer. ,vol. 136, ,(2015) , 10.1002/IJC.29210
P G Johnston, S Kaye, Capecitabine: a novel agent for the treatment of solid tumors. Anti-Cancer Drugs. ,vol. 12, pp. 639- 646 ,(2001) , 10.1097/00001813-200109000-00001
George M. Sheldrick, Crystal structure refinement with SHELXL Acta Crystallographica Section C-crystal Structure Communications. ,vol. 71, pp. 3- 8 ,(2015) , 10.1107/S2053229614024218
Zhao-Jun Li, Yong Hou, Da-An Qin, Zhi-Min Jin, Mao-Lin Hu, Two Half-Sandwiched Ruthenium (II) Compounds Containing 5-Fluorouracil Derivatives: Synthesis and Study of DNA Intercalation PLOS ONE. ,vol. 10, pp. e0120211- ,(2015) , 10.1371/JOURNAL.PONE.0120211
Edjane R Dos Santos, Melina A Mondelli, Lucas V Pozzi, Rodrigo S Corrêa, Heloisa S Salistre-de-Araújo, Fernando R Pavan, Clarice QF Leite, Javier Ellena, Valéria RS Malta, Sérgio P Machado, Alzir A Batista, None, New ruthenium(II)/phosphines/diimines complexes: Promising antitumor (human breast cancer) and Mycobacterium tuberculosis fighting agents Polyhedron. ,vol. 51, pp. 292- 297 ,(2013) , 10.1016/J.POLY.2013.01.004
Francesc X. Sureda, Elena Escubedo, Cec�lia Gabriel, Jaume Comas, Jorge Camarasa, Antonio Camins, Mitochondrial membrane potential measurement in rat cerebellar neurons by flow cytometry. Cytometry. ,vol. 28, pp. 74- 80 ,(1997) , 10.1002/(SICI)1097-0320(19970501)28:1<74::AID-CYTO9>3.0.CO;2-H
I. Nicoletti, G. Migliorati, M.C. Pagliacci, F. Grignani, C. Riccardi, A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry Journal of Immunological Methods. ,vol. 139, pp. 271- 279 ,(1991) , 10.1016/0022-1759(91)90198-O
Daniel B. Longley, D. Paul Harkin, Patrick G. Johnston, 5-Fluorouracil: mechanisms of action and clinical strategies Nature Reviews Cancer. ,vol. 3, pp. 330- 338 ,(2003) , 10.1038/NRC1074
MONICA LAMBERTI, STEFANIA PORTO, SILVIA ZAPPAVIGNA, PAOLA STIUSO, VIRGINIA TIRINO, VINCENZO DESIDERIO, LUIGI MELE, MICHELE CARAGLIA, Levofolene modulates apoptosis induced by 5-fluorouracil through autophagy inhibition: clinical and occupational implications. International Journal of Oncology. ,vol. 46, pp. 1893- 1900 ,(2015) , 10.3892/IJO.2015.2904
Suzanne Leijen, Sjaak A. Burgers, Paul Baas, Dick Pluim, Matthijs Tibben, Erik van Werkhoven, Enzo Alessio, Gianni Sava, Jos H. Beijnen, Jan H. M. Schellens, Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy Investigational New Drugs. ,vol. 33, pp. 201- 214 ,(2015) , 10.1007/S10637-014-0179-1