Neurochemical bases of locomotion and ethanol stimulant effects.
作者： Tamara J. Phillips , Elaine H. Shent
DOI: 10.1016/S0074-7742(08)60669-8
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摘要: Publisher Summary The locomotor stimulant effect produced by alcohol (ethanol) is one of the measurable ethanol effects. Ethanol-induced euphoria in humans and stimulation rodents—a potential animal model human euphoria—have long been recognized latter has extensively characterized. As may influence development uncontrolled or excessive use, a solid understanding neurochemical substrates underlying such effects important. This chapter discusses three neurotransmitter substances—dopamine, glutamate γ-aminobutyric acid (GABA), glutamate—for control spontaneous locomotion. Studies suggest that CNS processes using these transmitter substances are involved determining on Particular emphasis this area research placed mesolimbic VTA/NAcc dopaminergic system VP/SI, which GABAergic terminate from NAcc. Glutamate detected both NAcc VP/SI postulated to mediate neurotransmission. These pathways do not act independently but, rather, interact produce final behavioral outcome. also involvement other systems as cholinergic, serotonergic, adrenergic ethanol's activating
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