Study of Serum Hepcidin as a Potential Mediator of the Disrupted Iron Metabolism in Obese Adolescents
作者： Hayam K. Nazif , Azza Abd El-Shaheed , Karima A. I. El-Shamy
DOI: 10.12816/0024114
关键词:
摘要: Background & Aims: The prevalence of obesity continues to rise in both developed and developing nations. An association between iron status has been described children adults. We aimed study the relation serum hepcidin level as well high sensitive CRP obese adolescents. Materials Methods : This work was conducted on 80 adolescents aging 12-14 years old, divided into two equal groups; non-obese. Anthropometric measurements, determination haemoglobin, iron, total binding capacity (TIBC), transferrin saturation, ferritin, soluble receptor (sTfR), (hs –CRP) were performed. Results:  Obese showed significantly lower levels ferritin saturation. Significant higher diastolic blood pressure, mean TIBC, sTfR, hs –CRP also found. Serum correlated positively with BMI hs- CRP, but negatively group. Conclusion: These data suggest that is an important modulator anemia patients. Obesity can be considered a low grade inflammatory state, stimulates production markers such which up-regulate synthesis. Keywords: Obesity,Hepcidin, Iron deficiency, Children
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