The Potential Role of Iron and Copper in Pediatric Obesity and Nonalcoholic Fatty Liver Disease.

摘要: Obesity is a rapidly growing health problem and paralleled by multitude of comorbidities, including nonalcoholic fatty liver disease (NAFLD). NAFLD has become the most common chronic in both adults children. The current understanding still fragmentary. While simple steatosis characterized interplay between excessive free acid accumulation hepatic insulin resistance, progression to NASH been related oxidative stress proinflammatory state with dysbalanced adipokine, cytokine levels, endotoxin-mediated immune response. In addition, suggested play central role for sequelae leading NASH. Trace elements are critical regulatory, immunologic, antioxidant functions resulting protection against inflammation peroxidation consequently known comorbidities obesity. Disruptions metal detoxification processes located plausibly development via stress. Perturbations iron copper (Cu) homeostasis have shown contribute pathogenesis NAFLD. This review presents data from pediatric studies. adult studies summarized where clinical relevance may be extrapolated obesity