Higher Hepcidin Levels in Adolescents with Obesity Are Associated with Metabolic Syndrome Dyslipidemia and Visceral Fat.

摘要: Tightly regulated iron metabolism prevents oxidative stress. Hepcidin is a hormone that regulates flow in plasma; its production induced by an overload and inflammation. It inhibits entry into the circulation blocking dietary absorption duodenum, release of recycled from macrophages exit stored hepatocytes. Varied signals responding to stores, erythropoietic activity host defense converge regulate hepcidin thereby affect homeostasis. Although it known increases when interleukin 6 (IL-6) increases, relationship between hepcidin, dyslipidemia, insulin resistance (IR) visceral adiposity index (VAI) adolescents with obesity unclear. In this cross-sectional study 29 obese 30 control subjects, we explored difference markers IL-6 non-obese adolescents, identified associations inflammation, atherogenic dyslipidemia IR. As compared lean controls, participants showed 67% higher hepcidin: 14,070.8 ± 7213.5 vs. 8419.1 4826.1 pg/mLc; 70% ferritin: 94.4 82.4 55.1 39.6 pg/mLa 120% IL-6: 2.0 (1.1–4.9) 0.9 (0.5–1.3) pg/mLd. Transferrin, soluble transferrin receptor total body (as measured sTFR/ferritin, log10 sTFR/ferritin ratio sTFR/log ferritin ratios) were not different two cohorts. whole cohort, correlated VAI (r = 0.29a), sd-LDL 0.31b), HOMA-IR 0.29a) 0.35c). TG 0.47b), VLDL-C 0.43b) smaller LDL2 0.39a). elevation linked more inflammation metabolic alterations than since other groups, except for ferritin. Studies addressing long-term effects levels their impact on subclinical anemia status are warranted. a p < 0.05; b p 0.01, c p 0.001 dp 0.0001.