Non-invasive (and minimally invasive) diagnosis of oesophageal varices.

作者: Roberto de Franchis

DOI: 10.1016/J.JHEP.2008.07.009

关键词:

摘要: Current guidelines recommend screening all cirrhotic patients by endoscopy, to identify at risk of bleeding who should undergo prophylactic treatment. However, since the prevalence varices in is variable, universal would imply a large number unnecessary endoscopies and heavy burden for endoscopy units. In addition, compliance programs may be hampered perceived unpleasantness endoscopy. Predicting presence oesophageal non-invasive means might increase permit restrict performance those with high probability having varices. Over years, several studies have addressed this issue assessing potential biochemical, clinical ultrasound parameters, transient elastography, CT scanning video capsule The platelet count/spleen diameter ratio, shown promising characteristics, although none them equivalent EGD. These methods are as preferable thus adherence programs. Whether will compensate lower sensitivity these alternative techniques, ultimately improve outcomes if more screening, crucial question that answered future.

参考文章(56)
C. BUREAU, S. METIVIER, J. M. PERON, J. SELVES, M. A. ROBIC, P. A. GOURRAUD, O. ROUQUET, E. DUPUIS, L. ALRIC, J. P. VINEL, Transient elastography accurately predicts presence of significant portal hypertension in patients with chronic liver disease. Alimentary Pharmacology & Therapeutics. ,vol. 27, pp. 1261- 1268 ,(2008) , 10.1111/J.1365-2036.2008.03701.X
Erik Christensen, Lis Fauerholdt, Poul Schlichting, Erik Juhl, Hemming Poulsen, Niels Tygstrup, CSL, Aspects of the Natural History of Gastrointestinal Bleeding in Cirrhosis and the Effect of Prednisone Gastroenterology. ,vol. 81, pp. 944- 952 ,(1981) , 10.1016/S0016-5085(81)80123-0
M Cottone, G D'Amico, A Maringhini, M Amuso, E Sciarrino, M Traina, M P Marcenò, G Fusco, G Dardanoni, L Pagliaro, Predictive value of ultrasonography in the screening of non-ascitic cirrhotic patients with large varices. Journal of Ultrasound in Medicine. ,vol. 5, pp. 189- 192 ,(1986) , 10.7863/JUM.1986.5.4.189
Gennaro D'Amico, Guadalupe Garcia-Tsao, Luigi Pagliaro, Natural history and prognostic indicators of survival in cirrhosis: A systematic review of 118 studies Journal of Hepatology. ,vol. 44, pp. 217- 231 ,(2006) , 10.1016/J.JHEP.2005.10.013
Francesco Vizzutti, Umberto Arena, Roberto G. Romanelli, Luigi Rega, Marco Foschi, Stefano Colagrande, Antonio Petrarca, Stefania Moscarella, Giacomo Belli, Anna Linda Zignego, Fabio Marra, Giacomo Laffi, Massimo Pinzani, Liver stiffness measurement predicts severe portal hypertension in patients with HCV-related cirrhosis. Hepatology. ,vol. 45, pp. 1290- 1297 ,(2007) , 10.1002/HEP.21665
Betsy Winkfield, Christophe Aubé, Pascal Burtin, Paul Calès, Inter-observer and intra-observer variability in hepatology. European Journal of Gastroenterology & Hepatology. ,vol. 15, pp. 959- 966 ,(2003) , 10.1097/00042737-200309000-00004
Janus Ong, Zobair M Younossi, Clinical predictors of large esophageal varices: how accurate are they? The American Journal of Gastroenterology. ,vol. 94, pp. 3103- 3105 ,(1999) , 10.1111/J.1572-0241.1999.3103_A.X
Farhad Kazemi, Adrien Kettaneh, Gisèle N’kontchou, Emmanuel Pinto, Nathalie Ganne-Carrie, Jean-Claude Trinchet, Michel Beaugrand, Liver stiffness measurement selects patients with cirrhosis at risk of bearing large oesophageal varices Journal of Hepatology. ,vol. 45, pp. 230- 235 ,(2006) , 10.1016/J.JHEP.2006.04.006
Gennaro D'Amico, Angelo Luca, 3 Natural history. Clinical-haemodynamic correlations. Prediction of the risk of bleeding Baillière's clinical gastroenterology. ,vol. 11, pp. 243- 256 ,(1997) , 10.1016/S0950-3528(97)90038-5