Efficacy of transient elastography in screening for large esophageal varices in patients with suspicious or proven liver cirrhosis

作者: Huay-Min WANG , Gin-Ho LO , Wen-Chi CHEN , Ping-I HSU , Hsien-Chung YU

DOI: 10.1111/J.1751-2980.2012.00603.X

关键词:

摘要: OBJECTIVE:  To evaluate the liver stiffness measurement (LSM) using transient elastography (TE) to predict risk of esophageal varices (EVs) in Chinese patients. METHODS:  In total, 46 patients with suspicious or proven cirrhosis underwent TE and biopsy. All participants were endoscopically screened for presence EVs large by two endoscopists who blinded LSM status. Large defined as more than 5 mm diameter. Receiver operating characteristic (ROC) curves both platelet count/spleen diameter (PC/SD) ratio predicting calculated. RESULTS:  Of patients, 30 (65%) had including 19 (41%) EVs. The area under ROC curve (AUROC) was 0.85 0.83 EVs, respectively. cut-off values ≥13.4 kPa ≥14.6 kPa Notably, AUROC PC/SD 0.92 but only 0.69 EVs. CONCLUSION:  can may identify require endoscopic surveillance.

参考文章(29)
Arnoldo Riquelme, Alejandro Soza, Álvaro Contreras, Gerty Barrios, Oslando Padilla, Paola Viviani, Rosa María Pérez-Ayuso, Francisco Barrera, Platelet count/spleen diameter ratio for non-invasive prediction of high risk esophageal varices in cirrhotic patients. Annals of Hepatology. ,vol. 8, pp. 325- 330 ,(2009) , 10.1016/S1665-2681(19)31745-4
C. BUREAU, S. METIVIER, J. M. PERON, J. SELVES, M. A. ROBIC, P. A. GOURRAUD, O. ROUQUET, E. DUPUIS, L. ALRIC, J. P. VINEL, Transient elastography accurately predicts presence of significant portal hypertension in patients with chronic liver disease. Alimentary Pharmacology & Therapeutics. ,vol. 27, pp. 1261- 1268 ,(2008) , 10.1111/J.1365-2036.2008.03701.X
Jérôme Boursier, Anselme Konaté, Gabriella Gorea, Stéphane Reaud, Emmanuel Quemener, Frédéric Oberti, Isabelle Hubert–Fouchard, Nina Dib, Paul Calès, Reproducibility of liver stiffness measurement by ultrasonographic elastometry. Clinical Gastroenterology and Hepatology. ,vol. 6, pp. 1263- 1269 ,(2008) , 10.1016/J.CGH.2008.07.006
Francesco Vizzutti, Umberto Arena, Roberto G. Romanelli, Luigi Rega, Marco Foschi, Stefano Colagrande, Antonio Petrarca, Stefania Moscarella, Giacomo Belli, Anna Linda Zignego, Fabio Marra, Giacomo Laffi, Massimo Pinzani, Liver stiffness measurement predicts severe portal hypertension in patients with HCV-related cirrhosis. Hepatology. ,vol. 45, pp. 1290- 1297 ,(2007) , 10.1002/HEP.21665
Farhad Kazemi, Adrien Kettaneh, Gisèle N’kontchou, Emmanuel Pinto, Nathalie Ganne-Carrie, Jean-Claude Trinchet, Michel Beaugrand, Liver stiffness measurement selects patients with cirrhosis at risk of bearing large oesophageal varices Journal of Hepatology. ,vol. 45, pp. 230- 235 ,(2006) , 10.1016/J.JHEP.2006.04.006
J. Swets, Measuring the accuracy of diagnostic systems Science. ,vol. 240, pp. 1285- 1293 ,(1988) , 10.1126/SCIENCE.3287615
Roberto de Franchis, Non-invasive (and minimally invasive) diagnosis of oesophageal varices. Journal of Hepatology. ,vol. 49, pp. 520- 527 ,(2008) , 10.1016/J.JHEP.2008.07.009
Kenneth J. Drobatz, Measures of accuracy and performance of diagnostic tests Journal of Veterinary Cardiology. ,vol. 11, ,(2009) , 10.1016/J.JVC.2009.03.004
Cándid Villanueva, Joaquim Balanzó, Variceal bleeding : pharmacological treatment and prophylactic strategies. Drugs. ,vol. 68, pp. 2303- 2324 ,(2008) , 10.2165/0003495-200868160-00004
Gin-Ho Lo, Wen-Chi Chen, Mei-Hsiu Chen, Chi-Pin Lin, Ching-Chu Lo, Ping-I Hsu, Jin-Shiung Cheng, Kwok-Hung Lai, Endoscopic ligation vs. nadolol in the prevention of first variceal bleeding in patients with cirrhosis. Gastrointestinal Endoscopy. ,vol. 59, pp. 333- 338 ,(2004) , 10.1016/S0016-5107(03)02819-0