Synthesis and biolocalization of water-soluble sapphyrins.
作者： Vladimir Král , Julian Davis , Andrei Andrievsky , Jarmila Kralová , Alla Synytsya
DOI: 10.1021/JM0104320
关键词:
摘要: The synthesis, characterization, and biolocalization properties of new, fully water-soluble sapphyrins is reported. These systems, which display light absorbing features that make them potential interest as photodynamic therapy (PDT) sensitizers, were found to localize selectively in pancreatic carcinoma tissue a xenographic murine model. In this model, the concentration ratios for malignant surrounding muscle be high 280 most favorable case. concentrations reported here, well porphyrin control system, determined function time type.
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