Biolocalisation and photochemical properties of two novel macrocyclic photosensitisers: a spectroscopic study.
作者： Alla Synytsya , Vladimı́r Král , Miroslava Blechová , Karel Volka
DOI: 10.1016/J.JPHOTOBIOL.2004.02.003
关键词:
摘要: Biolocalisation and photochemical properties of novel macrocyclic photosensitisers, guanidiniocarbonyl-substituted tetraphenylporphyrin (1) sugar-substituted sapphyrin (2) were investigated by spectroscopic methods. Both photosensitisers absorb in far visible region showed good tumour localisation. Photosensitiser 2 demonstrated significantly larger absolute relative to normal tissue (T/N) amount (330 microg g(-1) wet tissue, T/N=19.0) than photosensitiser 1 did (13 T/N=2.1). According iodometric uric acid assays, compound produced large 1O2 (phidelta=0.60-0.68), while non-significant production (phidelta=0.04). The electronic study confirms that only is able mediate photooxidation model compounds (BSA, poly(Trp), Tyr, Trp, GMP) after light irradiation. Pour activity was explained its self-aggregation. Raman indicated monomerised effectively damaged BSA calf thymus DNA excitation at the conditions high excess these macromolecules.
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