IGF-1R, IGF-1 and IGF-2 expression as potential prognostic and predictive markers in colorectal-cancer.
作者： Gerrit Peters , Silvia Gongoll , Cord Langner , Michael Mengel , Pompiliu Piso
DOI: 10.1007/S00428-003-0856-5
关键词:
摘要: Insulin-like growth factors (IGF-1 and IGF-2) the IGF-1 membrane receptor (IGF-1R) have been found to play a critical role in carcinogenesis of several tumors, among them colorectal cancer (CRC). To study prognostic impact these molecules, total number 713 cases CRC were examined for expression IGF-1, IGF-2, IGF-1R. The results correlated with other clinicopathological data clinical follow-up. was noted 53 (7.5%), IGF-2 88 (12.6%), IGF-1R 698 (99.6%) cases. There significant associations between two (P<0.00001), Ki-67 proliferation activity (P<0.05), tumor stage (P<0.005). positivity significantly worse outcome (P<0.005) only univariate, but not multivariate, survival analysis. A similar trend obtained patients IGF-1-positive CRC, reached statistical significance limited stages (pT1/pT2; P<0.01). Although synchronous subset is consistent an auto-/paracrine loop cell autostimulation, effect seems be value. However, identification IGF-positive might beneficial predictive reasons, as new molecular therapeutic approaches are aimed at IGF system related pathways.
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sci-hub.se 参考文章(37)
Roberto Labianca, Maria Adelaide Pessi, Giuseppina Zamparelli, Treatment of colorectal cancer. Current guidelines and future prospects for drug therapy. Drugs. ,vol. 53, pp. 593- 607 ,(1997) , 10.2165/00003495-199753040-00005
Marcelina Párrizas, Derek LeRoith, Insulin-like growth factor-1 inhibition of apoptosis is associated with increased expression of the bcl-xL gene product. Endocrinology. ,vol. 138, pp. 1355- 1358 ,(1997) , 10.1210/ENDO.138.3.5103
R W Furlanetto, S E Harwell, K K Frick, Insulin-like growth factor-I induces cyclin-D1 expression in MG63 human osteosarcoma cells in vitro. Molecular Endocrinology. ,vol. 8, pp. 510- 517 ,(1994) , 10.1210/MEND.8.4.8052269
Silvia Gongoll, Gerrit Peters, Michael Mengel, Pompiliu Piso, Jürgen Klempnauer, Hans Kreipe, Reinhard von Wasielewski, Prognostic significance of calcium-binding protein S100A4 in colorectal cancer Gastroenterology. ,vol. 123, pp. 1478- 1484 ,(2002) , 10.1053/GAST.2002.36606
H. Bleiberg, Colorectal cancer—Is there an alternative to 5-FU? European Journal of Cancer. ,vol. 33, pp. 536- 541 ,(1997) , 10.1016/S0959-8049(96)00481-9
Herbert Yu, Thomas Rohan, Role of the insulin-like growth factor family in cancer development and progression Journal of the National Cancer Institute. ,vol. 92, pp. 1472- 1489 ,(2000) , 10.1093/JNCI/92.18.1472
F. Rozen, X.-F. Yang, H. Huynh, M. Pollak, Antiproliferative Action of Vitamin D-Related Compounds and Insulin-Like Growth Factor-Binding Protein 5 Accumulation Journal of the National Cancer Institute. ,vol. 89, pp. 652- 656 ,(1997) , 10.1093/JNCI/89.9.652
R Lammers, G Carpenter, M Limardo, A Ullrich, P D Phillips, A M Soderquist, R Baserga, Z Pietrzkowski, Constitutive expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor abrogates all requirements for exogenous growth factors. Cell Growth & Differentiation. ,vol. 3, pp. 199- 205 ,(1992)
Wenbiao Liu, Lee M. Ellis, Brian Zebrowski, Yoshito Akagi, Keping Xie, Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I. Cancer Research. ,vol. 58, pp. 4008- 4014 ,(1998)
Rubin R, Baserga R, Insulin-like growth factor-I receptor. Its role in cell proliferation, apoptosis, and tumorigenicity. Laboratory Investigation. ,vol. 73, pp. 311- 331 ,(1995)