Porous ceramic titanium dioxide scaffolds promote bone formation in rabbit peri-implant cortical defect model

摘要: Titanium oxide (TiO₂) scaffolds have previously been reported to exhibit very low mechanical strength. However, we able produce a scaffold that features high interconnectivity, porosity of 91% and compressive strength above 1.2 MPa. This study analyzed the in vivo performance porous TiO₂ peri-implant cortical defect model rabbit. After 8 weeks healing, morphological microcomputed tomography analyses defects treated with had significantly higher bone volume, surface surface-to-volume ratio when compared sham, both marrow compartment. No adverse effects, i.e. tissue necrosis or inflammation as measured by lactate dehydrogenase activity real-time reverse transcription polymerase chain reaction analysis, were observed. Moreover, did not hinder growth onto adjacent titanium implant. Histology clearly demonstrated new formation sections presence newly formed close proximity Ti Bone-to-material contact between was observed histological sections. Islets also present compartment albeit small amounts. In conclusion, investigation demonstrates osseointegrate well are suitable for healing growth.