Activation of the kynurenine pathway in the acute phase of stroke and its role in fatigue and depression following stroke.

摘要: Many stroke survivors suffer from poststroke fatigue (PSF) and depression (PSD), indicating the importance of increasing base knowledge about mechanisms underlying these sequelae. The primary aim this study was to determine whether activation kynurenine (KYN) pathway predicts subsequent or in acute ischemic (AIS) patients. Acute serum levels 5-hydroxytryptamine (5-HT), tryptophan (TRP) catabolites (TRYCATs), competing amino acids, as well depression, were measured 45 TRP index [=100 × / (tyrosine + valine phenylalanine leucine isoleucine)] significantly lower patients with a Fatigue Severity Scale (FSS) score ≥4 at 12 months than those an FSS <4 (p = 0.039). Furthermore, level kynurenic acid phase higher 18 0.026). These findings indicate that PSF have bioavailability for 5-HT synthesis brain phase. However, they also appear greater neuroprotective potential In contrast PSF, no predictors PSD found. together previous studies suggest immune response indoleamine 2,3-dioxygenase follows AIS can predict but not PSD.