Endoplasmic reticulum stress inducers, but not imatinib, sensitize Philadelphia chromosome-positive leukemia cells to TRAIL-mediated apoptosis
作者： Itaru Kuroda , Hiroko Honna , Kumiko Goi , Keiko Kagami , Tetsuzo Tauchi
DOI: 10.1016/J.LEUKRES.2011.03.016
关键词:
摘要: Philadelphia-chromosome (Ph1)-positive leukemia cells frequently express death receptors DR4/DR5 for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and show high TRAIL-sensitivity. It has been reported that imatinib damaged cardiomyocytes by triggering endoplasmic reticulum (ER) stress ER inducers intensified TRAIL-sensitivity of some cancer upregulating expression. In fact, enhanced Ph1-positive contrast, did not induce responses unexpectedly downregulated expression, indicating sensitization to TRAIL-mediated cellular immunity through upregulation expression is unlikely.
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