Adenosine A3 receptor stimulation inhibits migration of human eosinophils

摘要: Activation of adenosine A3 receptors (A3-R) produced a dose-dependent reduction in the chemotaxis human eosinophils to platelet-activating factor (PAF), RANTES, and leukotriene B4 (LTB4) maximum 58, 48, 52%, respectively (P < 0.02). This effect was completely reversed by selective A3-R antagonists. In contrast, activation A1 or A2a-R did not affect PAF-induced eosinophil chemotaxis. PAF up-regulated expression CDllb/CD18, down-regulated L-selectin, also increased F-actin assembly eosinophils. The these markers influenced A3-R, A2a, A1-R stimulation. may play an important role inflammation inhibiting migration.