Effect of theophylline and adenosine on eosinophil function.
作者： Tatsuo Yukawa , Claus Kroegel , Pascal Chanez , Gordon Dent , Dieter Ukena
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摘要: Eosinophils may play a critical role in asthma and bronchial hyperresponsiveness, yet the effect of theophylline on their function is not certain. We have examined effects opsonized zymosan-induced Superoxide anion (O2−) release from guinea pig eosinophils harvested peritoneal cavity human obtained by differential centrifugation blood patients with peripheral eosinophilia. Theophylline at high concentration (10−3 M) inhibited O2− 27.6 ± 9.4% (mean SEM, p < 0.05), whereas clinically relevant concentrations (10−6 10−5 M), it significantly potentiated this 26.8 9.9% (p 0.05) 36.9 6.3% 0.01), respectively. 8-phenyltheophylline (10−7 to 10−3 which like inhibits adenosine receptors but does inhibit phosphodiesterase activity, produced potentiation all concentrations. Preincubation deaminase (0.1 U/ml) enhanced 72.4 15.2% add...
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