Mechanobiology of protein droplets: force arises from disorder
作者： Timothy J. Welsh , Yi Shen , Aviad Levin , Tuomas P.J. Knowles
DOI: 10.1016/J.CELL.2018.11.020
关键词:
摘要: The use of optogenetic approaches has revealed new roles for intracellular protein condensates described in two papers this issue Cell (Bracha et. al., 2018; Shin et al., 2018). These results show that growing are able to exert mechanical forces resulting chromatin rearrangement, establishing a role liquid-liquid phase separation the mechanobiology cell.
unirioja.es
sci-hub.se 参考文章(10)
Jennifer A. Doudna, Emmanuelle Charpentier, The new frontier of genome engineering with CRISPR-Cas9 Science. ,vol. 346, pp. 1258096- 1258096 ,(2014) , 10.1126/SCIENCE.1258096
C. P. Brangwynne, C. R. Eckmann, D. S. Courson, A. Rybarska, C. Hoege, J. Gharakhani, F. Julicher, A. A. Hyman, Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation Science. ,vol. 324, pp. 1729- 1732 ,(2009) , 10.1126/SCIENCE.1172046
Tetsuro Murakami, Seema Qamar, Julie Qiaojin Lin, Gabriele S. Kaminski Schierle, Eric Rees, Akinori Miyashita, Ana R. Costa, Roger B. Dodd, Fiona T.S. Chan, Claire H. Michel, Deborah Kronenberg-Versteeg, Yi Li, Seung-Pil Yang, Yosuke Wakutani, William Meadows, Rodylyn Rose Ferry, Liang Dong, Gian Gaetano Tartaglia, Giorgio Favrin, Wen-Lang Lin, Dennis W. Dickson, Mei Zhen, David Ron, Gerold Schmitt-Ulms, Paul E. Fraser, Neil A. Shneider, Christine Holt, Michele Vendruscolo, Clemens F. Kaminski, Peter St George-Hyslop, ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function Neuron. ,vol. 88, pp. 678- 690 ,(2015) , 10.1016/J.NEURON.2015.10.030
Job Dekker, Leonid Mirny, The 3D Genome as Moderator of Chromosomal Communication Cell. ,vol. 164, pp. 1110- 1121 ,(2016) , 10.1016/J.CELL.2016.02.007
Yongdae Shin, Joel Berry, Nicole Pannucci, Mikko P. Haataja, Jared E. Toettcher, Clifford P. Brangwynne, Spatiotemporal Control of Intracellular Phase Transitions Using Light-Activated optoDroplets Cell. ,vol. 168, pp. 159- 171.e14 ,(2017) , 10.1016/J.CELL.2016.11.054
Yongdae Shin, Clifford P. Brangwynne, Liquid phase condensation in cell physiology and disease. Science. ,vol. 357, pp. 1253- ,(2017) , 10.1126/SCIENCE.AAF4382
Shovamayee Maharana, Jie Wang, Dimitrios K. Papadopoulos, Doris Richter, Andrey Pozniakovsky, Ina Poser, Marc Bickle, Sandra Rizk, Jordina Guillén-Boixet, Titus M. Franzmann, Marcus Jahnel, Lara Marrone, Young-Tae Chang, Jared Sterneckert, Pavel Tomancak, Anthony A. Hyman, Simon Alberti, RNA buffers the phase separation behavior of prion-like RNA binding proteins Science. ,vol. 360, pp. 918- 921 ,(2018) , 10.1126/SCIENCE.AAR7366
Seema Qamar, GuoZhen Wang, Suzanne J. Randle, Francesco Simone Ruggeri, Juan A. Varela, Julie Qiaojin Lin, Emma C. Phillips, Akinori Miyashita, Declan Williams, Florian Ströhl, William Meadows, Rodylyn Ferry, Victoria J. Dardov, Gian G. Tartaglia, Lindsay A. Farrer, Gabriele S. Kaminski Schierle, Clemens F. Kaminski, Christine E. Holt, Paul E. Fraser, Gerold Schmitt-Ulms, David Klenerman, Tuomas Knowles, Michele Vendruscolo, Peter St George-Hyslop, FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions Cell. ,vol. 173, pp. 720- 734 ,(2018) , 10.1016/J.CELL.2018.03.056
Dan Bracha, Mackenzie T. Walls, Ming-Tzo Wei, Lian Zhu, Martin Kurian, José L. Avalos, Jared E. Toettcher, Clifford P. Brangwynne, Mapping Local and Global Liquid Phase Behavior in Living Cells Using Photo-Oligomerizable Seeds. Cell. ,vol. 175, pp. 407- ,(2018) , 10.1016/J.CELL.2018.10.048
Yongdae Shin, Yi-Che Chang, Daniel S.W. Lee, Joel Berry, David W. Sanders, Pierre Ronceray, Ned S. Wingreen, Mikko Haataja, Clifford P. Brangwynne, Liquid Nuclear Condensates Mechanically Sense and Restructure the Genome. Cell. ,vol. 175, pp. 1518- ,(2018) , 10.1016/J.CELL.2018.10.057