The proposed functions of membrane curvatures mediated by the BAR domain superfamily proteins.

摘要: The plasma membrane, the outermost surface of eukaryotic cells, contains various substructures, such as protrusions or invaginations, which are associated with diverse functions, including endocytosis and cell migration. These structures membrane can be considered tubules inverted (protrusions) membrane. There six modes curvature at classified by positive negative location (tip, neck shaft tubules). BAR domain superfamily proteins have structurally determined curvatures contact their BAR, F-BAR I-BAR domains, generate maintain curved membranes binding to Importantly, SH3 domains bind actin regulatory WASP/WAVE proteins, BAR/F-BAR/I-BAR domain-SH3 unit could orient filaments towards for each subcellular structure. tubulations also function in fusion fission.