Changes of serum hepatitis B virus DNA in two types of clinical events preceding spontaneous hepatitis B e antigen seroconversion in chronic type B hepatitis.

摘要: Two types of clinical events, acute exacerbation and uneventful course, precede spontaneous HBeAg seroconversion to its antibody (anti-HBe) in chronic type B hepatitis. To examine the possible mechanism responsible for these two serial serum specimens from 75 patients who underwent were assayed hepatitis virus DNA by slot blot hybridization with 32P-labeled cloned as probe. Of patients, 47 (62.7%) had episodes (ALT greater than 300 IU per liter) within 3 months prior seroconversion. All high levels (greater 1,000 pg ml) at onset exacerbation. Their disappears shortly before or simultaneously clearance 27 (57.4%) persisted but decreasing 2 40 20 patients. Most alpha-fetoprotein evidence bridging hepatic necrosis. In contrast, was undetectable a minimum (3-17) 28 an course Twenty well-documented levels, normal little extensive necrosis far back 6 seroconversion.(ABSTRACT TRUNCATED AT 250 WORDS)